This gene encodes a mammalian peptidase that, at neutral pH, removes tripeptides from the N terminus of longer peptides. The protein has a specialized function that is essential for some MHC class I antigen presentation. The protein is a high molecular mass serine exopeptidase; the amino acid sequence surrounding the serine residue at the active site is similar to the peptidases of the subtilisin class rather than the trypsin class. [provided by RefSeq, Jul 2008]
Transcription factors with Perturb-seq knockdown data for TPP2. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = TPP2 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of TPP2, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr13:102,393,776–102,395,161 | 202.4 kb | Distal (>10kb) Multiome | 543 | |
| chr13:102,399,703–102,401,411 | 196.6 kb | Distal (>10kb) Multiome | 331 | |
| chr13:102,401,930–102,402,839 | 194.5 kb | Distal (>10kb) Multiome | 191 | |
| chr13:102,587,909–102,588,277 | 8.7 kb | Proximal (<10kb) | 12 | |
| chr13:102,591,759–102,592,780 | 4.7 kb | Proximal (<10kb) Multiome | 578 | |
| chr13:102,596,004–102,597,912 | 106 bp | At TSS Multiome | 918 | |
| chr13:102,598,190–102,598,515 | 1.2 kb | Proximal (<10kb) | 61 | |
| chr13:102,772,804–102,774,609 | 176.8 kb | Distal (>10kb) Multiome HiCAR | 683 | |
| chr13:102,798,454–102,800,933 | 203.5 kb | Distal (>10kb) Multiome HiCAR | 954 | |
| chr13:102,845,306–102,846,942 | 248.9 kb | Distal (>10kb) Multiome HiCAR | 1003 |
Genomic view of the TPP2 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.