This gene encodes beta-tropomyosin, a member of the actin filament binding protein family, and mainly expressed in slow, type 1 muscle fibers. Mutations in this gene can alter the expression of other sarcomeric tropomyosin proteins, and cause cap disease, nemaline myopathy and distal arthrogryposis syndromes. Alternatively spliced transcript variants encoding different isoforms have been found for this gene.[provided by RefSeq, Mar 2009]
Transcription factors with Perturb-seq knockdown data for TPM2. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = TPM2 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of TPM2, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr9:35,406,111–35,407,050 | 283.3 kb | Distal (>10kb) Multiome | 145 | |
| chr9:35,424,217–35,425,184 | 265.3 kb | Distal (>10kb) Multiome | 171 | |
| chr9:35,489,223–35,490,919 | 200.0 kb | Distal (>10kb) Multiome | 918 | |
| chr9:35,603,584–35,606,173 | 85.7 kb | Distal (>10kb) Multiome | 918 | |
| chr9:35,645,821–35,647,298 | 44.0 kb | Distal (>10kb) Multiome | 734 | |
| chr9:35,657,275–35,659,114 | 31.9 kb | Distal (>10kb) Multiome | 1156 | |
| chr9:35,664,903–35,665,580 | 24.7 kb | Distal (>10kb) Multiome HiCAR | 814 | |
| chr9:35,675,371–35,676,451 | 14.0 kb | Distal (>10kb) Multiome | 223 | |
| chr9:35,680,794–35,681,086 | 8.8 kb | Proximal (<10kb) | 67 | |
| chr9:35,689,224–35,691,525 | 1.3 kb | Proximal (<10kb) Multiome | 541 | |
| chr9:35,696,646–35,696,857 | 6.7 kb | Proximal (<10kb) | 204 | |
| chr9:35,731,682–35,733,531 | 42.4 kb | Distal (>10kb) Multiome | 920 | |
| chr9:35,748,884–35,750,005 | 59.4 kb | Distal (>10kb) Multiome | 667 | |
| chr9:35,756,620–35,757,642 | 67.1 kb | Distal (>10kb) Multiome | 810 | |
| chr9:35,790,361–35,791,220 | 100.6 kb | Distal (>10kb) Multiome | 282 | |
| chr9:35,791,337–35,791,986 | 101.8 kb | Distal (>10kb) Multiome | 98 | |
| chr9:35,811,906–35,812,486 | 122.3 kb | Distal (>10kb) Multiome | 610 | |
| chr9:35,814,402–35,815,681 | 125.3 kb | Distal (>10kb) Multiome | 896 | |
| chr9:35,828,657–35,829,781 | 139.4 kb | Distal (>10kb) Multiome | 419 | |
| chr9:35,845,853–35,846,711 | 156.4 kb | Distal (>10kb) Multiome | 141 |
Genomic view of the TPM2 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.