The protein encoded by this gene is similar to oxidoreductases, which are enzymes involved in cellular responses to oxidative stresses and irradiation. This gene is induced by the tumor suppressor p53 and is thought to be involved in p53-mediated cell death. It contains a p53 consensus binding site in its promoter region and a downstream pentanucleotide microsatellite sequence. P53 has been shown to transcriptionally activate this gene by interacting with the downstream pentanucleotide microsatellite sequence. The microsatellite is polymorphic, with a varying number of pentanucleotide repeats directly correlated with the extent of transcriptional activation by p53. It has been suggested that the microsatellite polymorphism may be associated with differential susceptibility to cancer. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, May 2011]
Transcription factors with Perturb-seq knockdown data for TP53I3. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = TP53I3 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of TP53I3, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr2:23,925,864–23,928,023 | 158.0 kb | Distal (>10kb) Multiome | 1102 | |
| chr2:23,939,310–23,941,043 | 144.7 kb | Distal (>10kb) Multiome | 856 | |
| chr2:24,009,633–24,010,873 | 75.0 kb | Distal (>10kb) Multiome | 382 | |
| chr2:24,046,941–24,048,071 | 37.7 kb | Distal (>10kb) Multiome | 719 | |
| chr2:24,049,244–24,050,644 | 35.5 kb | Distal (>10kb) Multiome | 554 | |
| chr2:24,075,859–24,077,721 | 8.5 kb | Proximal (<10kb) Multiome | 1100 | |
| chr2:24,083,513–24,085,355 | 799 bp | At TSS Multiome | 1088 | |
| chr2:24,123,015–24,123,986 | 38.3 kb | Distal (>10kb) Multiome | 899 | |
| chr2:24,191,824–24,192,305 | 106.8 kb | Distal (>10kb) Multiome | 68 | |
| chr2:24,280,210–24,280,709 | 195.2 kb | Distal (>10kb) Multiome | 38 | |
| chr2:24,315,559–24,316,125 | 230.5 kb | Distal (>10kb) Multiome | 99 | |
| chr2:24,359,764–24,361,015 | 275.3 kb | Distal (>10kb) Multiome | 909 |
Genomic view of the TP53I3 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.