TOMM40

translocase of outer mitochondrial membrane 40 | C19orf1, D19S1177E, PER-EC1, PEREC1, TOM40

The protein encoded by this gene is localized in the outer membrane of the mitochondria. It is the channel-forming subunit of the translocase of the mitochondrial outer membrane (TOM) complex that is essential for import of protein precursors into mitochondria. Alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Aug 2015]

Member of: DE-1 Developmental clusters: GC3

Biological processes 24 terms

membrane (GO:0016020)mitochondria-associated endoplasmic reticulum membrane contact site (GO:0044233)mitochondrial inner membrane (GO:0005743)mitochondrial outer membrane (GO:0005741)mitochondrial outer membrane (GO:0005741)mitochondrial outer membrane (GO:0005741)mitochondrial outer membrane translocase complex (GO:0005742)mitochondrial outer membrane translocase complex (GO:0005742)mitochondrion (GO:0005739)mitochondrion (GO:0005739)mitochondrion (GO:0005739)mitochondrion targeting sequence binding (GO:0030943)protein binding (GO:0005515)protein import into mitochondrial matrix (GO:0030150)protein import into mitochondrial matrix (GO:0030150)protein import into mitochondrial matrix (GO:0030150)protein import into mitochondrial matrix (GO:0030150)protein insertion into mitochondrial outer membrane (GO:0045040)protein localization to mitochondrion (GO:0070585)transmembrane protein transporter activity (GO:0008320)transmembrane protein transporter activity (GO:0008320)transmembrane protein transporter activity (GO:0008320)transmembrane protein transporter activity (GO:0008320)transmembrane transport (GO:0055085)

Expression (TPM)

TFs regulating TOMM40 0 TFs

Transcription factors with Perturb-seq knockdown data for TOMM40. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = TOMM40 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.

TF	Mean coef	Binding	Outlier	TF→Gene link

Rows:

Elements linked to TOMM40

Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of TOMM40, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.

Element	Dist. to TSS	Link type	TFs
chr19:44,643,571–44,644,620	247.3 kb	Distal (>10kb) Multiome	710
chr19:44,747,085–44,747,789	143.7 kb	Distal (>10kb) Multiome	653
chr19:44,757,112–44,758,480	133.8 kb	Distal (>10kb) Multiome	209
chr19:44,758,633–44,759,104	132.3 kb	Distal (>10kb) Multiome	80
chr19:44,770,589–44,771,108	120.5 kb	Distal (>10kb) Multiome	367
chr19:44,777,671–44,778,314	113.3 kb	Distal (>10kb) Multiome	353
chr19:44,800,231–44,800,829	90.6 kb	Distal (>10kb) Multiome	508
chr19:44,807,965–44,809,338	83.1 kb	Distal (>10kb) Multiome	652
chr19:44,844,448–44,848,668	46.4 kb	Distal (>10kb) Multiome	1047
chr19:44,890,209–44,891,796	322 bp	At TSS Multiome	952
chr19:44,903,686–44,904,241	12.6 kb	Distal (>10kb) Multiome	666
chr19:44,905,114–44,907,037	15.5 kb	Distal (>10kb) Multiome	645
chr19:44,913,546–44,915,671	23.9 kb	Distal (>10kb) Multiome	587
chr19:44,926,693–44,927,388	36.0 kb	Distal (>10kb) Multiome	277
chr19:44,954,641–44,955,824	64.0 kb	Distal (>10kb) Multiome	835
chr19:45,001,031–45,002,639	110.2 kb	Distal (>10kb) Multiome	694
chr19:45,038,879–45,039,566	147.9 kb	Distal (>10kb) Multiome	800
chr19:45,075,125–45,076,814	185.3 kb	Distal (>10kb) Multiome	710
chr19:45,078,897–45,080,647	188.9 kb	Distal (>10kb) Multiome	1012
chr19:45,091,042–45,093,574	201.8 kb	Distal (>10kb) Multiome	959
chr19:45,177,803–45,179,711	287.3 kb	Distal (>10kb) Multiome	899

Genome Browser

Genomic view of the TOMM40 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.