Predicted to enable actin binding activity. Involved in protein localization. Located in cytosol and focal adhesion. [provided by Alliance of Genome Resources, Jul 2025]
Transcription factors with Perturb-seq knockdown data for TNS4. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = TNS4 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of TNS4, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr17:40,218,712–40,219,963 | 282.2 kb | Distal (>10kb) Multiome | 901 | |
| chr17:40,287,308–40,288,608 | 213.9 kb | Distal (>10kb) Multiome | 870 | |
| chr17:40,306,565–40,307,697 | 194.6 kb | Distal (>10kb) Multiome | 366 | |
| chr17:40,317,794–40,318,727 | 183.4 kb | Distal (>10kb) Multiome | 799 | |
| chr17:40,341,205–40,342,644 | 159.7 kb | Distal (>10kb) Multiome | 835 | |
| chr17:40,344,939–40,346,042 | 156.2 kb | Distal (>10kb) Multiome | 730 | |
| chr17:40,362,469–40,363,831 | 138.8 kb | Distal (>10kb) Multiome | 846 | |
| chr17:40,417,289–40,418,494 | 83.6 kb | Distal (>10kb) Multiome | 793 | |
| chr17:40,442,866–40,444,146 | 58.1 kb | Distal (>10kb) Multiome | 774 | |
| chr17:40,483,550–40,484,556 | 17.7 kb | Distal (>10kb) Multiome | 84 | |
| chr17:40,499,140–40,499,767 | 2.1 kb | Proximal (<10kb) Multiome | 358 | |
| chr17:40,615,478–40,615,916 | 114.1 kb | Distal (>10kb) Multiome | 297 | |
| chr17:40,637,853–40,638,362 | 136.5 kb | Distal (>10kb) Multiome | 83 | |
| chr17:40,735,202–40,736,205 | 234.0 kb | Distal (>10kb) Multiome | 21 |
Genomic view of the TNS4 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.