Enables RNA binding activity. Involved in positive regulation of nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay; positive regulation of nuclear-transcribed mRNA poly(A) tail shortening; and regulatory ncRNA-mediated gene silencing. Acts upstream of with a positive effect on miRNA-mediated gene silencing by inhibition of translation. Predicted to be located in cytosol. Predicted to be active in P-body and nucleoplasm. Implicated in subserous uterine fibroid and uterine fibroid. [provided by Alliance of Genome Resources, Jul 2025]
Transcription factors with Perturb-seq knockdown data for TNRC6B. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = TNRC6B upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of TNRC6B, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr22:39,532,183–39,533,171 | 512.0 kb | Distal (>10kb) Multiome HiCAR | 799 | |
| chr22:39,534,113–39,535,455 | 509.8 kb | Distal (>10kb) Multiome HiCAR | 621 | |
| chr22:39,968,248–39,969,062 | 76.2 kb | Distal (>10kb) Multiome | 99 | |
| chr22:39,994,434–39,995,793 | 49.9 kb | Distal (>10kb) Multiome | 287 | |
| chr22:40,036,714–40,036,908 | 7.9 kb | Proximal (<10kb) | 222 | |
| chr22:40,043,949–40,045,800 | 292 bp | At TSS Multiome | 871 | |
| chr22:40,176,907–40,177,289 | 132.2 kb | Distal (>10kb) Multiome | 461 | |
| chr22:40,177,538–40,178,026 | 133.0 kb | Distal (>10kb) Multiome | 616 | |
| chr22:40,179,208–40,179,418 | 1.3 kb | Proximal (<10kb) | 214 | |
| chr22:40,187,442–40,188,012 | 142.9 kb | Distal (>10kb) Multiome | 86 | |
| chr22:40,345,883–40,347,047 | 301.7 kb | Distal (>10kb) Multiome | 955 | |
| chr22:40,370,270–40,371,111 | 325.8 kb | Distal (>10kb) Multiome | 630 |
Genomic view of the TNRC6B locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.