This gene encodes a member of the trinucleotide repeat containing 6 protein family. The protein functions in post-transcriptional gene silencing through the RNA interference (RNAi) and microRNA pathways. The protein associates with messenger RNAs and Argonaute proteins in cytoplasmic bodies known as GW-bodies or P-bodies. Inhibiting expression of this gene delocalizes other GW-body proteins and impairs RNAi and microRNA-induced gene silencing. [provided by RefSeq, Jul 2008]
Transcription factors with Perturb-seq knockdown data for TNRC6A. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = TNRC6A upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of TNRC6A, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr16:24,482,577–24,483,221 | 246.7 kb | Distal (>10kb) Multiome | 74 | |
| chr16:24,523,560–24,524,356 | 205.8 kb | Distal (>10kb) Multiome | 101 | |
| chr16:24,538,906–24,540,348 | 190.2 kb | Distal (>10kb) Multiome | 1039 | |
| chr16:24,729,291–24,730,185 | 60 bp | At TSS Multiome | 831 | |
| chr16:25,014,631–25,015,917 | 285.6 kb | Distal (>10kb) Multiome | 754 |
Genomic view of the TNRC6A locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.