Predicted to enable chromatin binding activity. Located in cytosol; mitochondrion; and nucleus. [provided by Alliance of Genome Resources, Jul 2025]
Transcription factors with Perturb-seq knockdown data for TNRC18. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = TNRC18 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of TNRC18, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr7:5,189,698–5,190,896 | 217.2 kb | Distal (>10kb) Multiome | 725 | |
| chr7:5,240,214–5,240,895 | 167.0 kb | Distal (>10kb) Multiome | 613 | |
| chr7:5,296,049–5,297,455 | 110.6 kb | Distal (>10kb) Multiome | 191 | |
| chr7:5,401,296–5,401,948 | 5.8 kb | Proximal (<10kb) Multiome | 104 | |
| chr7:5,406,932–5,408,289 | 271 bp | At TSS Multiome | 281 | |
| chr7:5,412,740–5,413,653 | 5.9 kb | Proximal (<10kb) Multiome | 341 | |
| chr7:5,417,700–5,419,525 | 11.5 kb | Distal (>10kb) Multiome | 714 | |
| chr7:5,421,720–5,422,676 | 1.2 kb | Proximal (<10kb) | 485 | |
| chr7:5,423,102–5,425,439 | 16.7 kb | Distal (>10kb) Multiome | 834 | |
| chr7:5,425,593–5,426,138 | 1.8 kb | Proximal (<10kb) | 645 | |
| chr7:5,426,416–5,429,142 | 19.6 kb | Distal (>10kb) Multiome | 1072 | |
| chr7:5,450,591–5,451,143 | 43.5 kb | Distal (>10kb) Multiome | 306 | |
| chr7:5,486,725–5,487,360 | 79.6 kb | Distal (>10kb) Multiome | 621 | |
| chr7:5,494,650–5,495,099 | 87.4 kb | Distal (>10kb) Multiome | 515 | |
| chr7:5,513,480–5,514,175 | 106.5 kb | Distal (>10kb) Multiome | 815 | |
| chr7:5,524,684–5,527,073 | 119.2 kb | Distal (>10kb) Multiome | 736 | |
| chr7:5,529,088–5,532,313 | 122.6 kb | Distal (>10kb) Multiome | 1081 | |
| chr7:5,554,765–5,555,676 | 147.8 kb | Distal (>10kb) Multiome | 643 | |
| chr7:5,555,801–5,557,053 | 149.2 kb | Distal (>10kb) Multiome | 807 | |
| chr7:5,558,744–5,559,347 | 151.7 kb | Distal (>10kb) Multiome | 525 | |
| chr7:5,562,000–5,564,024 | 154.7 kb | Distal (>10kb) Multiome | 859 | |
| chr7:5,569,367–5,570,943 | 162.9 kb | Distal (>10kb) Multiome | 694 | |
| chr7:5,574,238–5,575,433 | 167.5 kb | Distal (>10kb) Multiome | 447 | |
| chr7:5,591,580–5,596,769 | 185.4 kb | Distal (>10kb) Multiome | 1056 | |
| chr7:5,606,973–5,608,439 | 200.3 kb | Distal (>10kb) Multiome | 322 |
Genomic view of the TNRC18 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.