The protein encoded by this gene is a member of the tumor necrosis factor (TNF) ligand family. This protein is a ligand for TNFRSF14, which is a member of the tumor necrosis factor receptor superfamily, and which is also known as a herpesvirus entry mediator (HVEM). This protein may function as a costimulatory factor for the activation of lymphoid cells and as a deterrent to infection by herpesvirus. This protein has been shown to stimulate the proliferation of T cells, and trigger apoptosis of various tumor cells. This protein is also reported to prevent tumor necrosis factor alpha mediated apoptosis in primary hepatocyte. Two alternatively spliced transcript variant encoding distinct isoforms have been reported. [provided by RefSeq, Jul 2008]
Transcription factors with Perturb-seq knockdown data for TNFSF14. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = TNFSF14 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of TNFSF14, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr19:6,372,272–6,374,427 | 296.7 kb | Distal (>10kb) Multiome | 925 | |
| chr19:6,392,902–6,394,077 | 276.6 kb | Distal (>10kb) Multiome | 767 | |
| chr19:6,423,613–6,425,899 | 244.9 kb | Distal (>10kb) Multiome | 956 | |
| chr19:6,458,960–6,460,940 | 209.7 kb | Distal (>10kb) Multiome | 859 | |
| chr19:6,463,863–6,464,838 | 205.9 kb | Distal (>10kb) Multiome | 526 | |
| chr19:6,470,903–6,471,589 | 198.9 kb | Distal (>10kb) Multiome | 26 | |
| chr19:6,475,386–6,477,353 | 193.5 kb | Distal (>10kb) Multiome | 419 | |
| chr19:6,515,952–6,517,331 | 153.9 kb | Distal (>10kb) Multiome | 732 | |
| chr19:6,530,842–6,531,584 | 139.1 kb | Distal (>10kb) Multiome | 640 | |
| chr19:6,551,766–6,552,224 | 118.1 kb | Distal (>10kb) Multiome | 403 | |
| chr19:6,656,104–6,656,671 | 13.7 kb | Distal (>10kb) Multiome | 10 | |
| chr19:6,661,103–6,661,799 | 8.5 kb | Proximal (<10kb) Multiome | 83 | |
| chr19:6,677,927–6,678,212 | 7.8 kb | Proximal (<10kb) | 188 | |
| chr19:6,718,413–6,719,236 | 48.8 kb | Distal (>10kb) Multiome | 284 | |
| chr19:6,729,971–6,731,015 | 60.5 kb | Distal (>10kb) Multiome | 470 | |
| chr19:6,736,423–6,741,197 | 67.5 kb | Distal (>10kb) Multiome | 1129 | |
| chr19:6,752,403–6,754,362 | 83.6 kb | Distal (>10kb) Multiome | 886 | |
| chr19:6,767,097–6,768,193 | 97.5 kb | Distal (>10kb) Multiome | 549 |
Genomic view of the TNFSF14 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.