This gene encodes a protein that belongs to the transmembrane and tetratricopeptide repeat-containing protein family. [provided by RefSeq, May 2010]
Transcription factors with Perturb-seq knockdown data for TMTC3. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = TMTC3 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of TMTC3, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr12:88,034,997–88,036,230 | 106.7 kb | Distal (>10kb) Multiome | 873 | |
| chr12:88,141,512–88,143,080 | 125 bp | At TSS Multiome | 892 | |
| chr12:88,143,757–88,144,303 | 1.5 kb | Proximal (<10kb) | 35 | |
| chr12:88,145,517–88,146,485 | 3.2 kb | Proximal (<10kb) | 77 | |
| chr12:88,921,388–88,922,852 | 779.8 kb | Distal (>10kb) Multiome HiCAR | 153 | |
| chr12:88,942,685–88,944,156 | 801.2 kb | Distal (>10kb) Multiome HiCAR | 122 |
Genomic view of the TMTC3 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.