This gene encodes an actin sequestering protein which plays a role in regulation of actin polymerization. The protein is also involved in cell proliferation, migration, and differentiation. This gene escapes X inactivation and has a homolog on chromosome Y. [provided by RefSeq, Jul 2008]
Transcription factors with Perturb-seq knockdown data for TMSB4X. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = TMSB4X upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of TMSB4X, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chrX:12,790,978–12,792,312 | 183.6 kb | Distal (>10kb) Multiome | 502 | |
| chrX:12,946,827–12,947,613 | 28.0 kb | Distal (>10kb) Multiome | 422 | |
| chrX:12,970,729–12,971,194 | 3.9 kb | Proximal (<10kb) | 189 | |
| chrX:12,974,537–12,975,757 | 80 bp | At TSS Multiome | 603 | |
| chrX:12,976,162–12,976,464 | 1.1 kb | Proximal (<10kb) | 241 | |
| chrX:12,978,298–12,978,601 | 3.2 kb | Proximal (<10kb) | 344 | |
| chrX:13,013,668–13,014,732 | 39.0 kb | Distal (>10kb) Multiome | 301 | |
| chrX:13,030,065–13,030,946 | 55.3 kb | Distal (>10kb) Multiome | 344 | |
| chrX:13,688,926–13,689,830 | 714.1 kb | Distal (>10kb) Multiome HiCAR | 608 |
Genomic view of the TMSB4X locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.