This gene encodes a member of the tropomodulin family. The encoded protein is an actin-capping protein that regulates tropomyosin by binding to its N-terminus, inhibiting depolymerization and elongation of the pointed end of actin filaments and thereby influencing the structure of the erythrocyte membrane skeleton. Multiple transcript variants encoding the same protein have been found for this gene. [provided by RefSeq, Oct 2009]
Transcription factors with Perturb-seq knockdown data for TMOD1. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = TMOD1 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of TMOD1, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr9:97,220,933–97,222,786 | 280.0 kb | Distal (>10kb) Multiome | 231 | |
| chr9:97,231,971–97,232,981 | 269.2 kb | Distal (>10kb) Multiome | 260 | |
| chr9:97,238,002–97,238,892 | 263.2 kb | Distal (>10kb) Multiome | 684 | |
| chr9:97,306,799–97,308,104 | 194.3 kb | Distal (>10kb) Multiome | 182 | |
| chr9:97,386,832–97,387,759 | 114.5 kb | Distal (>10kb) Multiome | 555 | |
| chr9:97,411,603–97,412,682 | 89.6 kb | Distal (>10kb) Multiome | 864 | |
| chr9:97,436,823–97,437,760 | 64.2 kb | Distal (>10kb) Multiome | 98 | |
| chr9:97,501,163–97,503,374 | 149 bp | At TSS Multiome | 581 | |
| chr9:97,503,559–97,503,990 | 1.9 kb | Proximal (<10kb) | 222 | |
| chr9:97,504,465–97,505,110 | 2.8 kb | Proximal (<10kb) | 200 | |
| chr9:97,506,486–97,506,703 | 4.8 kb | Proximal (<10kb) | 14 | |
| chr9:97,598,751–97,599,712 | 97.4 kb | Distal (>10kb) Multiome | 274 | |
| chr9:97,632,371–97,634,267 | 131.8 kb | Distal (>10kb) Multiome | 1027 | |
| chr9:97,696,750–97,697,733 | 195.7 kb | Distal (>10kb) Multiome | 836 | |
| chr9:97,741,053–97,741,796 | 239.7 kb | Distal (>10kb) Multiome | 305 |
Genomic view of the TMOD1 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.