Enables P-type magnesium transporter activity. Involved in magnesium ion transport from cytosol to endoplasmic reticulum. Is active in endoplasmic reticulum membrane. [provided by Alliance of Genome Resources, Jul 2025]
Transcription factors with Perturb-seq knockdown data for TMEM94. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = TMEM94 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of TMEM94, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr17:75,182,199–75,183,441 | 273.6 kb | Distal (>10kb) Multiome | 908 | |
| chr17:75,205,060–75,205,995 | 251.2 kb | Distal (>10kb) Multiome | 975 | |
| chr17:75,240,373–75,240,941 | 216.0 kb | Distal (>10kb) Multiome | 436 | |
| chr17:75,261,304–75,262,404 | 194.9 kb | Distal (>10kb) Multiome | 983 | |
| chr17:75,270,231–75,271,942 | 185.4 kb | Distal (>10kb) Multiome | 946 | |
| chr17:75,288,761–75,289,874 | 167.1 kb | Distal (>10kb) Multiome | 941 | |
| chr17:75,346,809–75,347,324 | 109.5 kb | Distal (>10kb) Multiome | 265 | |
| chr17:75,393,479–75,394,300 | 62.7 kb | Distal (>10kb) Multiome | 834 | |
| chr17:75,404,856–75,406,161 | 50.9 kb | Distal (>10kb) Multiome | 917 | |
| chr17:75,456,149–75,457,264 | 79 bp | At TSS Multiome | 865 | |
| chr17:75,457,373–75,457,571 | 714 bp | At TSS | 391 | |
| chr17:75,481,081–75,481,680 | 24.7 kb | Distal (>10kb) Multiome | 64 | |
| chr17:75,514,425–75,517,171 | 59.0 kb | Distal (>10kb) Multiome | 1158 | |
| chr17:75,524,764–75,527,160 | 68.9 kb | Distal (>10kb) Multiome | 951 | |
| chr17:75,549,465–75,550,388 | 93.3 kb | Distal (>10kb) Multiome | 602 | |
| chr17:75,587,697–75,590,735 | 132.7 kb | Distal (>10kb) Multiome | 744 | |
| chr17:75,633,694–75,634,328 | 177.4 kb | Distal (>10kb) Multiome | 559 | |
| chr17:75,666,763–75,667,767 | 210.6 kb | Distal (>10kb) Multiome | 783 | |
| chr17:75,720,933–75,721,693 | 264.7 kb | Distal (>10kb) Multiome | 509 | |
| chr17:75,753,534–75,754,285 | 297.2 kb | Distal (>10kb) Multiome | 699 |
Genomic view of the TMEM94 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.