Predicted to be involved in late endosome to vacuole transport via multivesicular body sorting pathway. Located in endoplasmic reticulum. [provided by Alliance of Genome Resources, Jul 2025]
Transcription factors with Perturb-seq knockdown data for TMEM50B. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = TMEM50B upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of TMEM50B, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr21:33,229,605–33,230,926 | 250.0 kb | Distal (>10kb) Multiome | 722 | |
| chr21:33,266,016–33,266,841 | 213.6 kb | Distal (>10kb) Multiome | 604 | |
| chr21:33,324,272–33,325,694 | 155.1 kb | Distal (>10kb) Multiome | 1015 | |
| chr21:33,402,567–33,402,985 | 77.1 kb | Distal (>10kb) Multiome | 218 | |
| chr21:33,403,116–33,404,351 | 76.6 kb | Distal (>10kb) Multiome | 570 | |
| chr21:33,478,861–33,480,615 | 156 bp | At TSS Multiome | 839 | |
| chr21:33,491,033–33,492,145 | 11.7 kb | Distal (>10kb) Multiome | 740 | |
| chr21:33,541,871–33,543,585 | 62.1 kb | Distal (>10kb) Multiome | 996 | |
| chr21:33,587,947–33,589,340 | 108.8 kb | Distal (>10kb) Multiome | 866 | |
| chr21:33,641,108–33,643,411 | 162.2 kb | Distal (>10kb) Multiome | 1018 |
Genomic view of the TMEM50B locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.