Enables protein homodimerization activity. Predicted to be involved in transmembrane transport. Located in cytosol; dendrite; and plasma membrane. [provided by Alliance of Genome Resources, Jul 2025]
Transcription factors with Perturb-seq knockdown data for TMEM266. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = TMEM266 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of TMEM266, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr15:75,823,901–75,824,543 | 235.8 kb | Distal (>10kb) Multiome | 98 | |
| chr15:75,842,738–75,844,503 | 216.7 kb | Distal (>10kb) Multiome | 842 | |
| chr15:75,903,363–75,904,635 | 156.0 kb | Distal (>10kb) Multiome | 958 | |
| chr15:76,033,743–76,034,907 | 25.7 kb | Distal (>10kb) Multiome | 131 | |
| chr15:76,057,341–76,057,650 | 2.3 kb | Proximal (<10kb) | 128 | |
| chr15:76,058,953–76,060,346 | 132 bp | At TSS Multiome | 463 | |
| chr15:76,139,361–76,140,331 | 79.8 kb | Distal (>10kb) Multiome | 257 | |
| chr15:76,253,843–76,254,335 | 194.1 kb | Distal (>10kb) Multiome | 59 | |
| chr15:76,310,960–76,312,031 | 251.5 kb | Distal (>10kb) Multiome | 980 | |
| chr15:76,335,834–76,337,186 | 276.7 kb | Distal (>10kb) Multiome | 781 | |
| chr15:76,337,664–76,338,596 | 278.2 kb | Distal (>10kb) Multiome | 603 | |
| chr15:76,341,048–76,343,196 | 282.8 kb | Distal (>10kb) Multiome | 257 | |
| chr15:76,345,613–76,346,889 | 286.4 kb | Distal (>10kb) Multiome | 577 |
Genomic view of the TMEM266 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.