Enables dolichyl-phosphate-mannose-protein mannosyltransferase activity. Involved in protein maturation. Is active in endoplasmic reticulum membrane. Implicated in T-cell non-Hodgkin lymphoma; non-Hodgkin lymphoma; and stomach cancer. [provided by Alliance of Genome Resources, Jul 2025]
Transcription factors with Perturb-seq knockdown data for TMEM260. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = TMEM260 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of TMEM260, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr14:55,411,377–55,412,204 | 1167.9 kb | Distal (>10kb) Multiome HiCAR | 795 | |
| chr14:56,552,658–56,553,598 | 26.9 kb | Distal (>10kb) Multiome | 60 | |
| chr14:56,578,056–56,578,506 | 1.3 kb | Proximal (<10kb) | 25 | |
| chr14:56,579,396–56,580,264 | 136 bp | At TSS Multiome | 723 | |
| chr14:56,585,434–56,585,824 | 5.6 kb | Proximal (<10kb) | 133 | |
| chr14:56,657,366–56,658,170 | 78.0 kb | Distal (>10kb) Multiome | 55 | |
| chr14:56,659,300–56,659,979 | 79.8 kb | Distal (>10kb) Multiome | 126 | |
| chr14:56,794,034–56,795,658 | 214.7 kb | Distal (>10kb) Multiome | 177 | |
| chr14:56,797,476–56,799,717 | 219.2 kb | Distal (>10kb) Multiome HiCAR | 305 | |
| chr14:56,804,880–56,806,970 | 226.0 kb | Distal (>10kb) Multiome | 343 | |
| chr14:56,808,566–56,809,371 | 229.2 kb | Distal (>10kb) Multiome | 138 | |
| chr14:56,846,930–56,847,795 | 267.5 kb | Distal (>10kb) Multiome | 173 | |
| chr14:56,855,868–56,856,570 | 276.3 kb | Distal (>10kb) Multiome | 256 | |
| chr14:56,858,307–56,858,852 | 278.8 kb | Distal (>10kb) Multiome | 104 | |
| chr14:57,268,159–57,269,344 | 688.9 kb | Distal (>10kb) Multiome HiCAR | 916 |
Genomic view of the TMEM260 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.