Predicted to enable transmembrane transporter activity. Predicted to be involved in transmembrane transport. Predicted to be active in membrane. [provided by Alliance of Genome Resources, Jul 2025]
Transcription factors with Perturb-seq knockdown data for TMEM184C. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = TMEM184C upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of TMEM184C, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr4:145,909,209–145,909,939 | 1707.8 kb | Distal (>10kb) Multiome HiCAR | 176 | |
| chr4:147,011,345–147,012,301 | 605.8 kb | Distal (>10kb) Multiome HiCAR | 135 | |
| chr4:147,116,988–147,118,019 | 499.8 kb | Distal (>10kb) Multiome HiCAR | 207 | |
| chr4:147,480,463–147,482,217 | 136.1 kb | Distal (>10kb) Multiome | 379 | |
| chr4:147,522,274–147,523,482 | 94.3 kb | Distal (>10kb) Multiome | 84 | |
| chr4:147,616,952–147,618,103 | 7 bp | At TSS Multiome | 744 | |
| chr4:147,683,720–147,684,759 | 66.8 kb | Distal (>10kb) Multiome | 824 | |
| chr4:147,730,889–147,733,228 | 114.7 kb | Distal (>10kb) Multiome | 724 |
Genomic view of the TMEM184C locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.