Predicted to be a structural constituent of ribosome. Predicted to be located in ribosome. [provided by Alliance of Genome Resources, Jul 2025]
Transcription factors with Perturb-seq knockdown data for TMEM161B-DT. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = TMEM161B-DT upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of TMEM161B-DT, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr5:88,140,327–88,142,256 | 127.4 kb | Distal (>10kb) Multiome | 616 | |
| chr5:88,258,737–88,259,157 | 9.8 kb | Proximal (<10kb) | 6 | |
| chr5:88,268,309–88,269,790 | 2 bp | At TSS Multiome | 803 | |
| chr5:88,659,646–88,661,615 | 392.2 kb | Distal (>10kb) Multiome HiCAR | 570 | |
| chr5:88,674,048–88,676,457 | 407.1 kb | Distal (>10kb) Multiome HiCAR | 679 |
Genomic view of the TMEM161B-DT locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.