Involved in negative regulation of mitochondrial outer membrane permeabilization involved in apoptotic signaling pathway. Located in endoplasmic reticulum membrane and mitochondrial membrane. [provided by Alliance of Genome Resources, Jul 2025]
Transcription factors with Perturb-seq knockdown data for TMEM14A. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = TMEM14A upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of TMEM14A, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr6:52,413,171–52,413,920 | 257.5 kb | Distal (>10kb) Multiome HiCAR | 46 | |
| chr6:52,419,778–52,421,057 | 250.9 kb | Distal (>10kb) Multiome HiCAR | 913 | |
| chr6:52,576,332–52,577,737 | 94.0 kb | Distal (>10kb) Multiome | 1007 | |
| chr6:52,598,101–52,598,732 | 72.7 kb | Distal (>10kb) Multiome | 684 | |
| chr6:52,663,554–52,663,925 | 7.2 kb | Proximal (<10kb) | 364 | |
| chr6:52,664,088–52,665,240 | 6.7 kb | Proximal (<10kb) Multiome | 857 | |
| chr6:52,670,570–52,671,575 | 36 bp | At TSS Multiome | 843 | |
| chr6:52,672,502–52,673,137 | 1.4 kb | Proximal (<10kb) | 78 | |
| chr6:52,675,296–52,676,107 | 4.4 kb | Proximal (<10kb) Multiome | 62 | |
| chr6:52,855,940–52,856,582 | 185.2 kb | Distal (>10kb) Multiome | 166 | |
| chr6:52,861,065–52,861,720 | 190.3 kb | Distal (>10kb) Multiome | 105 |
Genomic view of the TMEM14A locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.