Involved in negative regulation of canonical Wnt signaling pathway and negative regulation of immature T cell proliferation in thymus. Located in cytoplasm and plasma membrane. [provided by Alliance of Genome Resources, Jul 2025]
Transcription factors with Perturb-seq knockdown data for TMEM131L. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = TMEM131L upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of TMEM131L, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr4:153,204,222–153,207,340 | 260.5 kb | Distal (>10kb) Multiome | 625 | |
| chr4:153,222,243–153,223,345 | 243.7 kb | Distal (>10kb) Multiome | 755 | |
| chr4:153,248,554–153,249,897 | 217.0 kb | Distal (>10kb) Multiome | 489 | |
| chr4:153,344,063–153,345,542 | 121.7 kb | Distal (>10kb) Multiome | 920 | |
| chr4:153,452,038–153,452,864 | 14.0 kb | Distal (>10kb) Multiome | 245 | |
| chr4:153,465,572–153,467,737 | 51 bp | At TSS Multiome | 862 | |
| chr4:153,536,072–153,536,529 | 70.0 kb | Distal (>10kb) Multiome | 95 | |
| chr4:153,683,798–153,685,200 | 218.4 kb | Distal (>10kb) Multiome | 432 | |
| chr4:153,759,037–153,760,663 | 293.6 kb | Distal (>10kb) Multiome | 280 |
Genomic view of the TMEM131L locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.