This gene encodes a highly glycosylated transmembrane protein with a high content of threonine and serine residues in its extracellular domain, similar to a broadly defined category of proteins termed mucins. Exposure of some cell types to anti-PORIMIN (pro-oncosis receptor inducing membrane injury) antibody, crosslinks this protein on the cell surface and induces a type of cell death termed oncosis. Oncosis is distinct from apoptosis and is characterized by a loss of cell membrane integrity without DNA fragmentation. This gene product is proposed to function as a cell surface receptor that mediates cell death. [provided by RefSeq, Jul 2008]
Transcription factors with Perturb-seq knockdown data for TMEM123. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = TMEM123 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of TMEM123, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr11:102,197,552–102,198,107 | 254.9 kb | Distal (>10kb) Multiome | 171 | |
| chr11:102,268,042–102,269,399 | 184.1 kb | Distal (>10kb) Multiome | 546 | |
| chr11:102,346,630–102,348,333 | 105.7 kb | Distal (>10kb) Multiome | 973 | |
| chr11:102,390,489–102,391,318 | 62.0 kb | Distal (>10kb) Multiome HiCAR | 305 | |
| chr11:102,449,667–102,449,920 | 2.9 kb | Proximal (<10kb) | 77 | |
| chr11:102,451,581–102,453,773 | 45 bp | At TSS Multiome | 995 | |
| chr11:102,454,369–102,454,870 | 1.5 kb | Proximal (<10kb) | 56 | |
| chr11:102,603,171–102,604,670 | 151.4 kb | Distal (>10kb) Multiome | 319 | |
| chr11:102,612,813–102,613,765 | 160.4 kb | Distal (>10kb) Multiome | 337 |
Genomic view of the TMEM123 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.