This gene encodes a member of the monovalent cation:proton antiporter 2 (CPA2) family of transporter proteins. Members of this family typically couple the export of monovalent cations, such as potassium or sodium, to the import of protons across cellular membranes. Mutations in this gene have been identified in patients with a rare inherited vision defect, cornea guttata with anterior polar cataract. [provided by RefSeq, Mar 2017]
Transcription factors with Perturb-seq knockdown data for TMCO3. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = TMCO3 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of TMCO3, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr13:113,208,078–113,210,214 | 282.2 kb | Distal (>10kb) Multiome | 1103 | |
| chr13:113,296,598–113,297,816 | 193.9 kb | Distal (>10kb) Multiome | 1104 | |
| chr13:113,393,735–113,394,451 | 96.9 kb | Distal (>10kb) Multiome | 576 | |
| chr13:113,397,604–113,398,329 | 93.1 kb | Distal (>10kb) Multiome | 76 | |
| chr13:113,489,310–113,491,886 | 149 bp | At TSS Multiome | 791 | |
| chr13:113,584,313–113,585,542 | 93.6 kb | Distal (>10kb) Multiome | 559 | |
| chr13:113,652,944–113,653,751 | 162.3 kb | Distal (>10kb) Multiome | 168 | |
| chr13:113,758,648–113,759,690 | 268.2 kb | Distal (>10kb) Multiome | 428 |
Genomic view of the TMCO3 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.