This gene encodes a zonula occluden that is a member of the membrane-associated guanylate kinase homolog family. The encoded protein functions as a component of the tight junction barrier in epithelial and endothelial cells and is necessary for proper assembly of tight junctions. Mutations in this gene have been identified in patients with hypercholanemia, and genomic duplication of a 270 kb region including this gene causes autosomal dominant deafness-51. Alternatively spliced transcripts encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Nov 2011]
Transcription factors with Perturb-seq knockdown data for TJP2. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = TJP2 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of TJP2, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr9:68,871,983–68,872,511 | 249.0 kb | Distal (>10kb) Multiome | 208 | |
| chr9:68,894,403–68,895,261 | 226.5 kb | Distal (>10kb) Multiome | 84 | |
| chr9:69,035,618–69,036,298 | 85.4 kb | Distal (>10kb) Multiome | 819 | |
| chr9:69,120,411–69,122,618 | 640 bp | At TSS Multiome | 809 | |
| chr9:69,173,641–69,174,717 | 52.8 kb | Distal (>10kb) Multiome | 542 | |
| chr9:69,324,469–69,325,896 | 203.6 kb | Distal (>10kb) Multiome | 399 | |
| chr9:69,409,753–69,410,516 | 288.9 kb | Distal (>10kb) Multiome | 93 | |
| chr9:69,412,310–69,413,137 | 291.6 kb | Distal (>10kb) Multiome | 218 |
Genomic view of the TJP2 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.