Enables snRNA methyltransferase activity. Involved in regulation of alternative mRNA splicing, via spliceosome. Part of tRNA methyltransferase complex. Is active in nucleus. [provided by Alliance of Genome Resources, Apr 2025]
Transcription factors with Perturb-seq knockdown data for THUMPD2. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = THUMPD2 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of THUMPD2, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr2:39,484,116–39,485,280 | 294.6 kb | Distal (>10kb) Multiome | 235 | |
| chr2:39,664,916–39,667,114 | 113.3 kb | Distal (>10kb) Multiome | 409 | |
| chr2:39,743,146–39,744,007 | 35.6 kb | Distal (>10kb) Multiome | 129 | |
| chr2:39,778,784–39,779,822 | 24 bp | At TSS Multiome | 957 | |
| chr2:39,787,585–39,787,957 | 8.3 kb | Proximal (<10kb) | 29 |
Genomic view of the THUMPD2 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.