Predicted to enable RNA binding activity. Involved in mRNA export from nucleus. Located in chromosome, telomeric region; cytosol; and nuclear speck. Part of THO complex part of transcription export complex. [provided by Alliance of Genome Resources, Jul 2025]
Transcription factors with Perturb-seq knockdown data for THOC7. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = THOC7 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of THOC7, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr3:63,594,941–63,595,549 | 268.6 kb | Distal (>10kb) Multiome | 102 | |
| chr3:63,617,033–63,617,742 | 246.3 kb | Distal (>10kb) Multiome | 26 | |
| chr3:63,645,132–63,645,996 | 218.2 kb | Distal (>10kb) Multiome | 90 | |
| chr3:63,725,749–63,726,278 | 137.9 kb | Distal (>10kb) Multiome | 193 | |
| chr3:63,847,826–63,848,634 | 15.7 kb | Distal (>10kb) Multiome | 147 | |
| chr3:63,863,192–63,864,606 | 12 bp | At TSS Multiome | 635 | |
| chr3:63,872,315–63,872,863 | 8.4 kb | Proximal (<10kb) | 136 | |
| chr3:63,911,642–63,913,487 | 48.3 kb | Distal (>10kb) Multiome | 823 | |
| chr3:64,023,033–64,023,678 | 159.6 kb | Distal (>10kb) Multiome | 925 | |
| chr3:64,030,557–64,031,016 | 167.0 kb | Distal (>10kb) Multiome | 509 | |
| chr3:64,063,306–64,064,385 | 200.0 kb | Distal (>10kb) Multiome | 142 |
Genomic view of the THOC7 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.