TFRC
transferrin receptor | CD71, TFR1, p90

This gene encodes a cell surface receptor necessary for cellular iron uptake by the process of receptor-mediated endocytosis. This receptor is required for erythropoiesis and neurologic development. Multiple alternatively spliced variants have been identified. [provided by RefSeq, Sep 2015]

Developmental clusters: GC4
Biological processes 92 terms
HFE-transferrin receptor complex (GO:1990712)HFE-transferrin receptor complex (GO:1990712)Hsp70 protein binding (GO:0030544)RNA binding (GO:0003723)acute-phase response (GO:0006953)basolateral plasma membrane (GO:0016323)blood microparticle (GO:0072562)cell surface (GO:0009986)cell surface (GO:0009986)cell surface (GO:0009986)cell surface receptor signaling pathway (GO:0007166)cellular response to xenobiotic stimulus (GO:0071466)clathrin-coated endocytic vesicle membrane (GO:0030669)clathrin-coated pit (GO:0005905)clathrin-coated pit (GO:0005905)cytoplasmic vesicle (GO:0031410)double-stranded RNA binding (GO:0003725)early endosome (GO:0005769)endosome (GO:0005768)endosome (GO:0005768)endosome (GO:0005768)endosome membrane (GO:0010008)endosome membrane (GO:0010008)external side of plasma membrane (GO:0009897)external side of plasma membrane (GO:0009897)external side of plasma membrane (GO:0009897)extracellular exosome (GO:0070062)extracellular exosome (GO:0070062)extracellular region (GO:0005576)extracellular region (GO:0005576)extracellular region (GO:0005576)extracellular vesicle (GO:1903561)glutamatergic synapse (GO:0098978)identical protein binding (GO:0042802)intracellular iron ion homeostasis (GO:0006879)intracellular iron ion homeostasis (GO:0006879)intracellular iron ion homeostasis (GO:0006879)intracellular signal transduction (GO:0035556)iron ion transport (GO:0006826)iron ion transport (GO:0006826)lysosome (GO:0005764)melanosome (GO:0042470)membrane (GO:0016020)membrane (GO:0016020)multicellular organismal-level iron ion homeostasis (GO:0060586)multicellular organismal-level iron ion homeostasis (GO:0060586)negative regulation of apoptotic process (GO:0043066)negative regulation of mitochondrial fusion (GO:0010637)osteoclast differentiation (GO:0030316)perinuclear region of cytoplasm (GO:0048471)perinuclear region of cytoplasm (GO:0048471)plasma membrane (GO:0005886)plasma membrane (GO:0005886)plasma membrane (GO:0005886)plasma membrane (GO:0005886)plasma membrane (GO:0005886)positive regulation of B cell proliferation (GO:0030890)positive regulation of T cell proliferation (GO:0042102)positive regulation of canonical NF-kappaB signal transduction (GO:0043123)positive regulation of gene expression (GO:0010628)positive regulation of isotype switching (GO:0045830)positive regulation of protein localization to nucleus (GO:1900182)positive regulation of protein-containing complex assembly (GO:0031334)postsynapse (GO:0098794)postsynaptic recycling endosome membrane (GO:0098944)protein binding (GO:0005515)protein homodimerization activity (GO:0042803)protein kinase binding (GO:0019901)protein-containing complex binding (GO:0044877)protein-folding chaperone binding (GO:0051087)receptor internalization (GO:0031623)receptor-mediated endocytosis (GO:0006898)receptor-mediated endocytosis (GO:0006898)recycling endosome (GO:0055037)recycling endosome (GO:0055037)recycling endosome membrane (GO:0055038)regulation of cell growth (GO:0001558)regulation of cell population proliferation (GO:0042127)regulation of postsynaptic membrane neurotransmitter receptor levels (GO:0099072)response to copper ion (GO:0046688)response to hypoxia (GO:0001666)response to iron ion (GO:0010039)response to manganese ion (GO:0010042)response to nutrient (GO:0007584)response to retinoic acid (GO:0032526)transferrin receptor activity (GO:0004998)transferrin receptor activity (GO:0004998)transferrin receptor activity (GO:0004998)transferrin receptor activity (GO:0004998)transferrin transport (GO:0033572)transferrin transport (GO:0033572)transport across blood-brain barrier (GO:0150104)
Expression (TPM)
TFRC — as a Regulated Gene

TFs regulating TFRC 0 TFs

Transcription factors with Perturb-seq knockdown data for TFRC. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = TFRC upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.

Data: Effect:
TF Mean coef Binding Outlier TF→Gene link

Elements linked to TFRC

Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of TFRC, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.

Accessibility Element Dist. to TSS Link type TFs
chr3:195,806,205–195,806,743 275.6 kb Distal (>10kb) Multiome 119
chr3:195,894,987–195,896,413 186.1 kb Distal (>10kb) Multiome 611
chr3:195,908,177–195,910,831 172.4 kb Distal (>10kb) Multiome 661
chr3:196,073,339–196,073,505 8.6 kb Proximal (<10kb) 239
chr3:196,081,045–196,082,675 8 bp At TSS Multiome 1081
chr3:196,085,579–196,086,028 3.5 kb Proximal (<10kb) 37
chr3:196,110,410–196,110,962 28.5 kb Distal (>10kb) Multiome 307
chr3:196,207,804–196,208,801 126.1 kb Distal (>10kb) Multiome 300
chr3:196,273,588–196,274,153 191.7 kb Distal (>10kb) Multiome 95
chr3:196,287,125–196,288,362 205.6 kb Distal (>10kb) Multiome 979
chr3:196,317,553–196,318,672 236.1 kb Distal (>10kb) Multiome 830

Genome Browser

Genomic view of the TFRC locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.

chr3:195,796,205 – 196,328,672
Proximal 1 kb Distal 10 kb Multiome HiCAR ATAC-seq RNA-seq
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