The protein encoded by this gene plays a role in establishing proper neuronal connectivity during development. Defects in this gene have been associated with hereditary essential tremor-5. [provided by RefSeq, Oct 2016]
Transcription factors with Perturb-seq knockdown data for TENM4. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = TENM4 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of TENM4, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr11:79,265,655–79,266,799 | 175.0 kb | Distal (>10kb) Multiome | 118 | |
| chr11:79,371,172–79,372,743 | 69.3 kb | Distal (>10kb) Multiome | 208 | |
| chr11:79,375,591–79,376,466 | 65.1 kb | Distal (>10kb) Multiome | 181 | |
| chr11:79,436,838–79,439,169 | 3.4 kb | Proximal (<10kb) Multiome | 355 | |
| chr11:79,439,660–79,441,551 | 56 bp | At TSS Multiome | 469 | |
| chr11:79,444,988–79,445,739 | 4.0 kb | Proximal (<10kb) | 164 | |
| chr11:79,447,103–79,447,738 | 6.1 kb | Proximal (<10kb) | 194 | |
| chr11:79,472,732–79,473,543 | 32.2 kb | Distal (>10kb) Multiome | 202 | |
| chr11:79,485,742–79,486,748 | 44.9 kb | Distal (>10kb) Multiome | 186 | |
| chr11:79,493,413–79,494,093 | 52.7 kb | Distal (>10kb) Multiome | 231 | |
| chr11:79,506,723–79,507,289 | 65.9 kb | Distal (>10kb) Multiome | 134 | |
| chr11:81,279,694–81,280,668 | 1839.2 kb | Distal (>10kb) Multiome HiCAR | 116 |
Genomic view of the TENM4 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.