This gene encodes a tethering factor involved in autophagy. The encoded protein is found at autolysosomes, and is involved in targeting protein aggregates, damaged mitochondria, and bacterial pathogens for autophagy [provided by RefSeq, Nov 2012]
Transcription factors with Perturb-seq knockdown data for TECPR1. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = TECPR1 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of TECPR1, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr7:97,971,853–97,972,772 | 280.0 kb | Distal (>10kb) Multiome | 763 | |
| chr7:97,973,121–97,973,850 | 278.6 kb | Distal (>10kb) Multiome | 130 | |
| chr7:98,034,095–98,034,783 | 217.6 kb | Distal (>10kb) Multiome | 131 | |
| chr7:98,051,142–98,051,601 | 200.9 kb | Distal (>10kb) Multiome | 248 | |
| chr7:98,106,660–98,107,619 | 145.3 kb | Distal (>10kb) Multiome | 870 | |
| chr7:98,251,470–98,252,647 | 5 bp | At TSS Multiome | 846 | |
| chr7:98,280,710–98,282,616 | 29.3 kb | Distal (>10kb) Multiome | 691 | |
| chr7:98,294,739–98,295,296 | 42.8 kb | Distal (>10kb) Multiome | 363 | |
| chr7:98,305,831–98,306,470 | 54.0 kb | Distal (>10kb) Multiome | 55 | |
| chr7:98,362,631–98,363,114 | 110.7 kb | Distal (>10kb) Multiome | 59 | |
| chr7:98,400,423–98,401,663 | 149.0 kb | Distal (>10kb) Multiome | 752 | |
| chr7:98,470,267–98,471,178 | 218.6 kb | Distal (>10kb) Multiome | 246 |
Genomic view of the TECPR1 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.