Acts upstream of or within spermatogenesis. Located in cytosol and nucleus. [provided by Alliance of Genome Resources, Jul 2025]
Transcription factors with Perturb-seq knockdown data for TDRP. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = TDRP upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of TDRP, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr8:273,949–274,784 | 270.4 kb | Distal (>10kb) Multiome | 503 | |
| chr8:406,397–407,555 | 137.9 kb | Distal (>10kb) Multiome | 433 | |
| chr8:537,094–537,407 | 7.4 kb | Proximal (<10kb) | 42 | |
| chr8:537,524–537,855 | 7.0 kb | Proximal (<10kb) | 10 | |
| chr8:537,993–538,429 | 6.4 kb | Proximal (<10kb) | 17 | |
| chr8:544,123–546,078 | 203 bp | At TSS Multiome | 661 | |
| chr8:546,271–546,553 | 1.4 kb | Proximal (<10kb) | 57 | |
| chr8:614,975–615,676 | 70.6 kb | Distal (>10kb) Multiome | 172 | |
| chr8:686,716–688,571 | 143.5 kb | Distal (>10kb) Multiome | 501 | |
| chr8:730,654–731,828 | 186.4 kb | Distal (>10kb) Multiome | 546 | |
| chr8:736,879–738,062 | 192.7 kb | Distal (>10kb) Multiome | 128 |
Genomic view of the TDRP locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.