This gene encodes a protein that contains a PHD-type zinc finger domain and likely functions as a transcription factor. The encoded protein plays a role proliferation and apoptosis of pancreatic beta cells. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jan 2016]
Transcription factors with Perturb-seq knockdown data for TCF19. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = TCF19 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of TCF19, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr6:30,880,638–30,881,295 | 277.6 kb | Distal (>10kb) Multiome | 124 | |
| chr6:30,882,560–30,883,422 | 275.7 kb | Distal (>10kb) Multiome | 308 | |
| chr6:30,883,625–30,885,122 | 274.0 kb | Distal (>10kb) Multiome | 538 | |
| chr6:30,907,770–30,908,494 | 250.5 kb | Distal (>10kb) Multiome | 1005 | |
| chr6:30,913,674–30,914,800 | 244.3 kb | Distal (>10kb) Multiome | 944 | |
| chr6:30,942,475–30,943,087 | 215.7 kb | Distal (>10kb) Multiome | 300 | |
| chr6:30,955,192–30,955,975 | 202.8 kb | Distal (>10kb) Multiome | 524 | |
| chr6:31,157,467–31,159,255 | 159 bp | At TSS Multiome | 740 | |
| chr6:31,159,320–31,159,933 | 798 bp | At TSS | 302 | |
| chr6:31,171,796–31,173,419 | 13.5 kb | Distal (>10kb) Multiome | 178 | |
| chr6:31,307,823–31,308,922 | 149.7 kb | Distal (>10kb) Multiome | 248 | |
| chr6:31,366,884–31,367,398 | 208.6 kb | Distal (>10kb) Multiome | 433 | |
| chr6:31,399,631–31,400,231 | 241.3 kb | Distal (>10kb) Multiome | 678 | |
| chr6:31,403,046–31,404,269 | 245.0 kb | Distal (>10kb) Multiome | 796 | |
| chr6:31,441,682–31,442,105 | 283.3 kb | Distal (>10kb) Multiome | 316 |
Genomic view of the TCF19 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.