This gene encodes a member of the transcription elongation factor A (SII)-like (TCEAL) gene family. This family is comprised of nuclear phosphoproteins that modulate transcription in a promoter context-dependent manner. Multiple family members are located on the X chromosome. Alternatively splicing results in multiple transcript variants. There is a pseudogene for this gene on chromosome 13. [provided by RefSeq, Apr 2015]
Transcription factors with Perturb-seq knockdown data for TCEAL4. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = TCEAL4 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of TCEAL4, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chrX:103,310,557–103,311,346 | 274.5 kb | Distal (>10kb) Multiome | 289 | |
| chrX:103,376,152–103,376,747 | 209.1 kb | Distal (>10kb) Multiome | 356 | |
| chrX:103,431,896–103,432,874 | 153.1 kb | Distal (>10kb) Multiome | 6 | |
| chrX:103,585,371–103,585,795 | at TSS | At TSS | 309 | |
| chrX:103,607,566–103,608,355 | 22.5 kb | Distal (>10kb) Multiome | 234 | |
| chrX:103,686,434–103,687,597 | 101.4 kb | Distal (>10kb) Multiome | 737 | |
| chrX:103,766,973–103,767,614 | 181.7 kb | Distal (>10kb) Multiome | 82 | |
| chrX:103,831,529–103,832,547 | 246.6 kb | Distal (>10kb) Multiome | 250 |
Genomic view of the TCEAL4 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.