Cofactor E is one of four proteins (cofactors A, D, E, and C) involved in the pathway leading to correctly folded beta-tubulin from folding intermediates. Cofactors A and D are believed to play a role in capturing and stabilizing beta-tubulin intermediates in a quasi-native confirmation. Cofactor E binds to the cofactor D/beta-tubulin complex; interaction with cofactor C then causes the release of beta-tubulin polypeptides that are committed to the native state. Two transcript variants encoding the same protein have been found for this gene. [provided by RefSeq, Jul 2008]
Transcription factors with Perturb-seq knockdown data for TBCE. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = TBCE upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of TBCE, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr1:235,093,150–235,094,131 | 273.7 kb | Distal (>10kb) Multiome | 491 | |
| chr1:235,128,387–235,130,613 | 237.3 kb | Distal (>10kb) Multiome | 1042 | |
| chr1:235,160,743–235,162,007 | 206.2 kb | Distal (>10kb) Multiome | 1015 | |
| chr1:235,304,634–235,305,365 | 62.4 kb | Distal (>10kb) Multiome | 220 | |
| chr1:235,326,947–235,329,481 | 38.9 kb | Distal (>10kb) Multiome | 1010 | |
| chr1:235,357,533–235,357,737 | 9.7 kb | Proximal (<10kb) | 40 | |
| chr1:235,367,126–235,367,788 | 42 bp | At TSS Multiome | 851 | |
| chr1:235,503,729–235,505,713 | 137.1 kb | Distal (>10kb) Multiome | 1129 | |
| chr1:235,546,455–235,547,226 | 179.3 kb | Distal (>10kb) Multiome | 80 | |
| chr1:235,642,093–235,643,505 | 275.8 kb | Distal (>10kb) Multiome | 410 | |
| chr1:235,648,967–235,650,841 | 282.7 kb | Distal (>10kb) Multiome | 689 |
Genomic view of the TBCE locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.