Predicted to enable GTPase activator activity. Predicted to be involved in blood circulation and positive regulation of cell population proliferation. Predicted to be located in membrane. [provided by Alliance of Genome Resources, Jul 2025]
Transcription factors with Perturb-seq knockdown data for TBC1D8. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = TBC1D8 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of TBC1D8, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr2:101,001,648–101,002,871 | 149.2 kb | Distal (>10kb) Multiome | 1082 | |
| chr2:101,145,590–101,145,800 | 5.6 kb | Proximal (<10kb) | 67 | |
| chr2:101,149,665–101,150,287 | 1.1 kb | Proximal (<10kb) | 311 | |
| chr2:101,150,573–101,153,105 | 60 bp | At TSS Multiome | 881 | |
| chr2:101,249,749–101,250,223 | 98.7 kb | Distal (>10kb) Multiome | 50 | |
| chr2:101,251,158–101,251,706 | 100.1 kb | Distal (>10kb) Multiome | 97 | |
| chr2:101,251,848–101,253,677 | 101.4 kb | Distal (>10kb) Multiome | 1083 | |
| chr2:101,307,900–101,309,246 | 157.4 kb | Distal (>10kb) Multiome | 997 | |
| chr2:101,386,609–101,387,979 | 236.0 kb | Distal (>10kb) Multiome | 493 |
Genomic view of the TBC1D8 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.