Enables protein kinase binding activity. Involved in negative regulation of autophagy; recycling endosome to Golgi transport; and regulation of autophagosome assembly. Located in several cellular components, including Golgi apparatus; autophagosome; and recycling endosome. [provided by Alliance of Genome Resources, Jul 2025]
Transcription factors with Perturb-seq knockdown data for TBC1D14. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = TBC1D14 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of TBC1D14, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr4:6,640,089–6,641,132 | 269.2 kb | Distal (>10kb) Multiome | 851 | |
| chr4:6,673,157–6,674,688 | 235.8 kb | Distal (>10kb) Multiome | 920 | |
| chr4:6,709,388–6,710,099 | 200.0 kb | Distal (>10kb) Multiome HiCAR | 693 | |
| chr4:6,715,775–6,716,910 | 193.6 kb | Distal (>10kb) Multiome HiCAR | 822 | |
| chr4:6,782,106–6,784,027 | 127.3 kb | Distal (>10kb) Multiome | 886 | |
| chr4:6,902,570–6,902,863 | 6.6 kb | Proximal (<10kb) | 169 | |
| chr4:6,907,856–6,908,033 | 1.4 kb | Proximal (<10kb) | 230 | |
| chr4:6,908,950–6,910,715 | 198 bp | At TSS Multiome | 820 | |
| chr4:6,986,472–6,987,825 | 77.3 kb | Distal (>10kb) Multiome | 762 | |
| chr4:7,007,023–7,007,815 | 97.6 kb | Distal (>10kb) Multiome | 59 | |
| chr4:7,042,101–7,044,552 | 133.3 kb | Distal (>10kb) Multiome | 741 | |
| chr4:7,067,444–7,068,837 | 158.4 kb | Distal (>10kb) Multiome HiCAR | 887 | |
| chr4:7,101,878–7,102,488 | 192.3 kb | Distal (>10kb) Multiome | 437 | |
| chr4:7,102,990–7,103,713 | 193.6 kb | Distal (>10kb) Multiome | 565 | |
| chr4:7,192,144–7,193,135 | 282.7 kb | Distal (>10kb) Multiome | 236 |
Genomic view of the TBC1D14 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.