Predicted to enable metal ion binding activity and nuclease activity. Located in mitochondrion. [provided by Alliance of Genome Resources, Apr 2025]
Transcription factors with Perturb-seq knockdown data for TATDN3. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = TATDN3 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of TATDN3, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr1:212,498,151–212,499,452 | 293.0 kb | Distal (>10kb) Multiome | 216 | |
| chr1:212,514,035–212,515,926 | 276.5 kb | Distal (>10kb) Multiome | 524 | |
| chr1:212,558,067–212,559,384 | 232.9 kb | Distal (>10kb) Multiome | 891 | |
| chr1:212,605,830–212,610,097 | 182.2 kb | Distal (>10kb) Multiome | 1097 | |
| chr1:212,629,910–212,630,849 | 161.6 kb | Distal (>10kb) Multiome | 331 | |
| chr1:212,665,118–212,665,789 | 126.4 kb | Distal (>10kb) Multiome | 678 | |
| chr1:212,698,874–212,700,500 | 92.5 kb | Distal (>10kb) Multiome | 710 | |
| chr1:212,791,461–212,792,424 | 48 bp | At TSS Multiome | 1108 | |
| chr1:212,857,574–212,859,115 | 66.2 kb | Distal (>10kb) Multiome HiCAR | 946 | |
| chr1:212,860,779–212,861,295 | 69.0 kb | Distal (>10kb) Multiome | 315 | |
| chr1:212,907,964–212,908,918 | 116.5 kb | Distal (>10kb) Multiome | 62 | |
| chr1:212,909,569–212,910,174 | 118.2 kb | Distal (>10kb) Multiome | 97 | |
| chr1:212,916,378–212,917,359 | 125.1 kb | Distal (>10kb) Multiome | 306 | |
| chr1:212,928,624–212,929,308 | 137.1 kb | Distal (>10kb) Multiome | 145 | |
| chr1:212,950,130–212,951,519 | 158.6 kb | Distal (>10kb) Multiome HiCAR | 457 | |
| chr1:212,967,458–212,968,096 | 176.0 kb | Distal (>10kb) Multiome | 178 | |
| chr1:213,015,122–213,015,983 | 223.7 kb | Distal (>10kb) Multiome | 888 | |
| chr1:213,050,888–213,051,797 | 259.4 kb | Distal (>10kb) Multiome | 880 | |
| chr1:213,066,260–213,067,034 | 274.7 kb | Distal (>10kb) Multiome | 70 |
Genomic view of the TATDN3 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.