The membrane-associated protein encoded by this gene is a member of the superfamily of ATP-binding cassette (ABC) transporters. ABC proteins transport various molecules across extra- and intra-cellular membranes. ABC genes are divided into seven distinct subfamilies (ABC1, MDR/TAP, MRP, ALD, OABP, GCN20, White). This protein is a member of the MDR/TAP subfamily. Members of the MDR/TAP subfamily are involved in multidrug resistance. This gene is located 7 kb telomeric to gene family member ABCB2. The protein encoded by this gene is involved in antigen presentation. This protein forms a heterodimer with ABCB2 in order to transport peptides from the cytoplasm to the endoplasmic reticulum. Mutations in this gene may be associated with ankylosing spondylitis, insulin-dependent diabetes mellitus, and celiac disease. Alternative splicing of this gene produces products which differ in peptide selectivity and level of restoration of surface expression of MHC class I molecules. [provided by RefSeq, Feb 2014]
Transcription factors with Perturb-seq knockdown data for TAP2. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = TAP2 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of TAP2, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr6:32,837,981–32,838,977 | 56 bp | At TSS Multiome | 821 | |
| chr6:32,844,222–32,845,071 | 6.0 kb | Proximal (<10kb) Multiome | 534 | |
| chr6:32,853,077–32,854,448 | 15.3 kb | Distal (>10kb) Multiome | 841 | |
| chr6:32,893,822–32,895,230 | 55.9 kb | Distal (>10kb) Multiome | 774 | |
| chr6:32,952,883–32,953,496 | 114.5 kb | Distal (>10kb) Multiome | 366 | |
| chr6:32,967,972–32,971,214 | 130.1 kb | Distal (>10kb) Multiome | 1227 | |
| chr6:32,971,467–32,973,408 | 133.3 kb | Distal (>10kb) Multiome | 1115 | |
| chr6:33,009,348–33,009,899 | 170.9 kb | Distal (>10kb) Multiome | 184 |
Genomic view of the TAP2 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.