This gene is a member of the synaptotagmin gene family and encodes a protein similar to other family members that mediate membrane trafficking in synaptic transmission. The encoded protein is a calcium-independent synaptotagmin. Mutations in this gene are a cause of autosomal recessive spinocerebellar ataxia-11 (SCAR11), and a t(1;3) translocation of this gene has been associated with neurodevelopmental abnormalities. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene, and a pseudogene of this gene is located on the long arm of chromosome 4. [provided by RefSeq, Dec 2011]
Transcription factors with Perturb-seq knockdown data for SYT14. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = SYT14 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of SYT14, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr1:209,747,459–209,748,502 | 190.3 kb | Distal (>10kb) Multiome | 723 | |
| chr1:209,784,214–209,785,171 | 153.6 kb | Distal (>10kb) Multiome | 859 | |
| chr1:209,805,245–209,806,661 | 132.0 kb | Distal (>10kb) Multiome | 472 | |
| chr1:209,827,579–209,828,429 | 110.2 kb | Distal (>10kb) Multiome | 833 | |
| chr1:209,888,562–209,889,538 | 49.3 kb | Distal (>10kb) Multiome | 75 | |
| chr1:209,937,461–209,938,825 | 89 bp | At TSS Multiome | 555 | |
| chr1:210,232,393–210,234,634 | 294.7 kb | Distal (>10kb) Multiome | 604 |
Genomic view of the SYT14 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.