Predicted to be involved in modulation of chemical synaptic transmission. Predicted to be located in membrane; neuron projection; and synaptic vesicle. Predicted to be active in hippocampal mossy fiber to CA3 synapse and synaptic vesicle membrane. [provided by Alliance of Genome Resources, Jul 2025]
Transcription factors with Perturb-seq knockdown data for SYNPR. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = SYNPR upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of SYNPR, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr3:63,015,509–63,016,203 | 262.4 kb | Distal (>10kb) Multiome | 184 | |
| chr3:63,036,208–63,036,700 | 241.8 kb | Distal (>10kb) Multiome | 55 | |
| chr3:63,278,086–63,279,034 | 96 bp | At TSS Multiome | 202 | |
| chr3:63,279,142–63,279,285 | 492 bp | At TSS | 41 | |
| chr3:63,343,624–63,344,070 | 65.5 kb | Distal (>10kb) Multiome | 374 | |
| chr3:63,344,742–63,345,145 | 6.3 kb | Proximal (<10kb) | 73 | |
| chr3:63,349,697–63,349,859 | 1.6 kb | Proximal (<10kb) | 74 | |
| chr3:63,351,258–63,352,191 | at TSS | At TSS | 146 |
Genomic view of the SYNPR locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.