Predicted to act upstream of or within negative regulation of programmed cell death. Located in condensed chromosome, centromeric region and nucleoplasm. [provided by Alliance of Genome Resources, Jul 2025]
Transcription factors with Perturb-seq knockdown data for SYCP2L. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = SYCP2L upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of SYCP2L, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr6:10,659,291–10,660,431 | 227.2 kb | Distal (>10kb) Multiome | 202 | |
| chr6:10,694,307–10,695,190 | 192.3 kb | Distal (>10kb) Multiome | 980 | |
| chr6:10,722,577–10,723,508 | 164.1 kb | Distal (>10kb) Multiome | 960 | |
| chr6:10,747,079–10,748,260 | 139.4 kb | Distal (>10kb) Multiome | 1006 | |
| chr6:10,837,383–10,838,947 | 48.6 kb | Distal (>10kb) Multiome | 773 | |
| chr6:10,881,601–10,882,372 | 4.7 kb | Proximal (<10kb) | 146 | |
| chr6:10,882,510–10,883,313 | 4.0 kb | Proximal (<10kb) Multiome | 144 | |
| chr6:10,883,851–10,884,267 | 2.8 kb | Proximal (<10kb) | 55 | |
| chr6:10,886,419–10,887,541 | 49 bp | At TSS Multiome | 615 | |
| chr6:10,954,597–10,954,989 | 8.3 kb | Proximal (<10kb) | 403 | |
| chr6:10,962,959–10,963,396 | at TSS | At TSS | 59 | |
| chr6:11,007,370–11,008,733 | 121.0 kb | Distal (>10kb) Multiome | 412 | |
| chr6:11,043,323–11,045,047 | 157.4 kb | Distal (>10kb) Multiome | 766 | |
| chr6:11,093,116–11,094,741 | 206.7 kb | Distal (>10kb) Multiome | 1088 |
Genomic view of the SYCP2L locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.