SUSD6

sushi domain containing 6 | KIAA0247

Involved in DNA damage response. Predicted to be located in membrane. [provided by Alliance of Genome Resources, Jul 2025]

Member of: DE-10 DE-10.1 Developmental clusters: GC1

Biological processes 4 terms

DNA damage response (GO:0006974)DNA damage response (GO:0006974)membrane (GO:0016020)protein binding (GO:0005515)

Expression (TPM)

TFs regulating SUSD6 0 TFs

Transcription factors with Perturb-seq knockdown data for SUSD6. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = SUSD6 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.

TF	Mean coef	Binding	Outlier	TF→Gene link

Rows:

Elements linked to SUSD6

Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of SUSD6, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.

Element	Dist. to TSS	Link type	TFs
chr14:69,397,842–69,399,035	213.1 kb	Distal (>10kb) Multiome	926
chr14:69,483,950–69,485,210	127.0 kb	Distal (>10kb) Multiome	334
chr14:69,547,663–69,548,492	63.5 kb	Distal (>10kb) Multiome	213
chr14:69,561,722–69,562,330	49.5 kb	Distal (>10kb) Multiome	67
chr14:69,571,579–69,572,640	39.5 kb	Distal (>10kb) Multiome	300
chr14:69,574,502–69,574,973	36.9 kb	Distal (>10kb) Multiome	302
chr14:69,603,655–69,603,854	7.7 kb	Proximal (<10kb)	198
chr14:69,611,065–69,612,800	56 bp	At TSS Multiome	628
chr14:69,713,212–69,713,782	101.9 kb	Distal (>10kb) Multiome HiCAR	240
chr14:69,726,783–69,727,436	115.4 kb	Distal (>10kb) Multiome HiCAR	527
chr14:69,766,760–69,768,278	155.4 kb	Distal (>10kb) Multiome	1012
chr14:69,879,235–69,879,856	267.8 kb	Distal (>10kb) Multiome	563

Genome Browser

Genomic view of the SUSD6 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.