Sulfite oxidase is a homodimeric protein localized to the intermembrane space of mitochondria. Each subunit contains a heme domain and a molybdopterin-binding domain. The enzyme catalyzes the oxidation of sulfite to sulfate, the final reaction in the oxidative degradation of the sulfur amino acids cysteine and methionine. Sulfite oxidase deficiency results in neurological abnormalities which are often fatal at an early age. Alternative splicing results in multiple transcript variants encoding identical proteins. [provided by RefSeq, Jul 2008]
Transcription factors with Perturb-seq knockdown data for SUOX. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = SUOX upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of SUOX, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr12:54,390,265–54,391,699 | 1605.9 kb | Distal (>10kb) Multiome HiCAR | 393 | |
| chr12:55,707,276–55,708,500 | 289.3 kb | Distal (>10kb) Multiome | 372 | |
| chr12:55,715,733–55,716,775 | 281.0 kb | Distal (>10kb) Multiome | 929 | |
| chr12:55,727,952–55,730,453 | 267.6 kb | Distal (>10kb) Multiome | 895 | |
| chr12:55,736,969–55,737,781 | 260.0 kb | Distal (>10kb) Multiome | 496 | |
| chr12:55,737,830–55,739,085 | 258.7 kb | Distal (>10kb) Multiome | 475 | |
| chr12:55,742,540–55,744,252 | 254.1 kb | Distal (>10kb) Multiome | 631 | |
| chr12:55,745,091–55,746,361 | 251.4 kb | Distal (>10kb) Multiome | 299 | |
| chr12:55,817,254–55,818,558 | 179.4 kb | Distal (>10kb) Multiome | 749 | |
| chr12:55,829,008–55,831,505 | 167.6 kb | Distal (>10kb) Multiome | 921 | |
| chr12:55,926,651–55,928,471 | 70.3 kb | Distal (>10kb) Multiome | 993 | |
| chr12:55,931,904–55,932,439 | 65.1 kb | Distal (>10kb) Multiome | 279 | |
| chr12:55,940,073–55,940,746 | 56.8 kb | Distal (>10kb) Multiome | 478 | |
| chr12:55,966,006–55,967,470 | 30.5 kb | Distal (>10kb) Multiome | 615 | |
| chr12:55,973,347–55,974,716 | 23.4 kb | Distal (>10kb) Multiome | 966 | |
| chr12:55,996,814–55,997,861 | 23 bp | At TSS Multiome | 680 | |
| chr12:55,999,651–56,000,093 | 2.4 kb | Proximal (<10kb) | 19 | |
| chr12:56,006,888–56,008,461 | 10.4 kb | Distal (>10kb) Multiome | 745 | |
| chr12:56,020,644–56,021,511 | 23.7 kb | Distal (>10kb) Multiome | 364 | |
| chr12:56,041,220–56,042,537 | 44.5 kb | Distal (>10kb) Multiome | 1035 | |
| chr12:56,078,964–56,081,015 | 82.0 kb | Distal (>10kb) Multiome | 1032 | |
| chr12:56,103,918–56,105,302 | 107.1 kb | Distal (>10kb) Multiome | 977 | |
| chr12:56,115,844–56,117,060 | 119.3 kb | Distal (>10kb) Multiome | 958 | |
| chr12:56,117,641–56,119,301 | 120.9 kb | Distal (>10kb) Multiome | 1052 | |
| chr12:56,126,181–56,126,640 | 129.1 kb | Distal (>10kb) Multiome | 671 | |
| chr12:56,127,552–56,129,104 | 130.9 kb | Distal (>10kb) Multiome | 800 | |
| chr12:56,151,724–56,153,003 | 155.2 kb | Distal (>10kb) Multiome | 830 | |
| chr12:56,157,307–56,159,499 | 161.0 kb | Distal (>10kb) Multiome | 1008 | |
| chr12:56,188,836–56,190,865 | 192.3 kb | Distal (>10kb) Multiome | 954 | |
| chr12:56,221,094–56,222,691 | 224.7 kb | Distal (>10kb) Multiome | 884 | |
| chr12:56,222,996–56,223,487 | 225.9 kb | Distal (>10kb) Multiome | 38 | |
| chr12:56,223,843–56,224,800 | 227.1 kb | Distal (>10kb) Multiome | 765 | |
| chr12:56,257,471–56,258,774 | 261.2 kb | Distal (>10kb) Multiome | 710 | |
| chr12:56,266,608–56,267,683 | 269.8 kb | Distal (>10kb) Multiome | 857 |
Genomic view of the SUOX locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.