SUMO1

small ubiquitin like modifier 1 | GMP1, OFC10, PIC1, SMT3C, SMT3H3, SUMO-1, UBL1

This gene encodes a protein that is a member of the SUMO (small ubiquitin-like modifier) protein family. It functions in a manner similar to ubiquitin in that it is bound to target proteins as part of a post-translational modification system. However, unlike ubiquitin which targets proteins for degradation, this protein is involved in a variety of cellular processes, such as nuclear transport, transcriptional regulation, apoptosis, and protein stability. It is not active until the last four amino acids of the carboxy-terminus have been cleaved off. Several pseudogenes have been reported for this gene. Alternate transcriptional splice variants encoding different isoforms have been characterized. [provided by RefSeq, Jul 2008]

Member of: DE-1 Developmental clusters: GC5

Biological processes 54 terms

DNA repair (GO:0006281)PML body (GO:0016605)PML body (GO:0016605)PML body (GO:0016605)PML body (GO:0016605)RNA binding (GO:0003723)cellular response to cadmium ion (GO:0071276)cellular response to heat (GO:0034605)cytoplasm (GO:0005737)cytosol (GO:0005829)enzyme binding (GO:0019899)negative regulation of DNA-templated transcription (GO:0045892)negative regulation of DNA-templated transcription (GO:0045892)negative regulation of action potential (GO:0045759)negative regulation of protein import into nucleus (GO:0042308)negative regulation of transcription by RNA polymerase II (GO:0000122)negative regulation of transcription initiation by RNA polymerase II (GO:0060633)nuclear body (GO:0016604)nuclear body (GO:0016604)nuclear membrane (GO:0031965)nuclear membrane (GO:0031965)nuclear pore (GO:0005643)nuclear speck (GO:0016607)nuclear stress granule (GO:0097165)nucleolus (GO:0005730)nucleoplasm (GO:0005654)nucleoplasm (GO:0005654)nucleus (GO:0005634)nucleus (GO:0005634)nucleus (GO:0005634)nucleus (GO:0005634)nucleus (GO:0005634)plasma membrane (GO:0005886)plasma membrane (GO:0005886)positive regulation of proteasomal ubiquitin-dependent protein catabolic process (GO:0032436)positive regulation of protein-containing complex assembly (GO:0031334)potassium channel regulator activity (GO:0015459)protein binding (GO:0005515)protein stabilization (GO:0050821)protein sumoylation (GO:0016925)protein sumoylation (GO:0016925)protein sumoylation (GO:0016925)protein sumoylation (GO:0016925)protein tag activity (GO:0031386)protein tag activity (GO:0031386)regulation of calcium ion transmembrane transport (GO:1903169)regulation of cardiac muscle cell contraction (GO:0086004)regulation of protein stability (GO:0031647)roof of mouth development (GO:0060021)small protein activating enzyme binding (GO:0044388)transporter activator activity (GO:0141109)ubiquitin protein ligase binding (GO:0031625)ubiquitin-like protein ligase binding (GO:0044389)ubiquitin-specific protease binding (GO:1990381)

Expression (TPM)

TFs regulating SUMO1 0 TFs

Transcription factors with Perturb-seq knockdown data for SUMO1. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = SUMO1 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.

TF	Mean coef	Binding	Outlier	TF→Gene link

Rows:

Elements linked to SUMO1

Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of SUMO1, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.

Element	Dist. to TSS	Link type	TFs
chr2:201,948,994–201,950,276	289.1 kb	Distal (>10kb) Multiome	334
chr2:201,972,639–201,973,266	265.6 kb	Distal (>10kb) Multiome	195
chr2:202,019,731–202,020,536	218.4 kb	Distal (>10kb) Multiome	118
chr2:202,023,052–202,024,286	215.0 kb	Distal (>10kb) Multiome	272
chr2:202,032,848–202,036,232	204.9 kb	Distal (>10kb) Multiome	769
chr2:202,038,976–202,040,047	198.9 kb	Distal (>10kb) Multiome	233
chr2:202,148,653–202,149,792	89.3 kb	Distal (>10kb) Multiome	213
chr2:202,163,899–202,164,942	74.1 kb	Distal (>10kb) Multiome	79
chr2:202,237,794–202,239,082	38 bp	At TSS Multiome	820
chr2:202,249,669–202,250,510	11.5 kb	Distal (>10kb) Multiome	213
chr2:202,265,167–202,266,195	27.1 kb	Distal (>10kb) Multiome	931
chr2:202,374,983–202,377,090	137.5 kb	Distal (>10kb) Multiome	979
chr2:202,417,747–202,419,134	180.1 kb	Distal (>10kb) Multiome	197
chr2:202,494,924–202,495,550	256.6 kb	Distal (>10kb) Multiome	49

Genome Browser

Genomic view of the SUMO1 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.