Enables several functions, including DNA binding activity; identical protein binding activity; and transcription coactivator activity. Involved in RNA polymerase II promoter clearance; protein homooligomerization; and regulation of nucleobase-containing compound metabolic process. Located in nucleolus and nucleoplasm. Part of transcription regulator complex. [provided by Alliance of Genome Resources, Jul 2025]
Transcription factors with Perturb-seq knockdown data for SUB1. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = SUB1 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of SUB1, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr5:32,287,695–32,288,492 | 297.4 kb | Distal (>10kb) Multiome | 161 | |
| chr5:32,312,016–32,313,764 | 272.5 kb | Distal (>10kb) Multiome | 877 | |
| chr5:32,443,333–32,445,482 | 140.8 kb | Distal (>10kb) Multiome | 960 | |
| chr5:32,463,190–32,463,817 | 122.0 kb | Distal (>10kb) Multiome HiCAR | 67 | |
| chr5:32,474,004–32,474,924 | 111.2 kb | Distal (>10kb) Multiome HiCAR | 130 | |
| chr5:32,500,148–32,500,972 | 85.1 kb | Distal (>10kb) Multiome HiCAR | 96 | |
| chr5:32,585,030–32,586,359 | 216 bp | At TSS Multiome | 894 | |
| chr5:32,711,666–32,714,486 | 128.6 kb | Distal (>10kb) Multiome | 419 |
Genomic view of the SUB1 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.