Enables armadillo repeat domain binding activity; nuclear estrogen receptor binding activity; and protein phosphatase 2A binding activity. Involved in Wnt signaling pathway and negative regulation of cell population proliferation. Located in bicellular tight junction. Part of FAR/SIN/STRIPAK complex. [provided by Alliance of Genome Resources, Jul 2025]
Transcription factors with Perturb-seq knockdown data for STRN. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = STRN upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of STRN, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr2:36,753,597–36,754,396 | 212.5 kb | Distal (>10kb) Multiome | 229 | |
| chr2:36,961,647–36,962,064 | 4.5 kb | Proximal (<10kb) | 17 | |
| chr2:36,963,157–36,963,393 | 3.1 kb | Proximal (<10kb) | 75 | |
| chr2:36,965,312–36,965,609 | 926 bp | At TSS | 67 | |
| chr2:36,965,735–36,967,324 | 107 bp | At TSS Multiome | 1026 | |
| chr2:37,083,780–37,086,187 | 119.3 kb | Distal (>10kb) Multiome | 938 | |
| chr2:37,156,055–37,157,536 | 190.4 kb | Distal (>10kb) Multiome | 702 | |
| chr2:37,205,153–37,205,870 | 238.9 kb | Distal (>10kb) Multiome | 157 | |
| chr2:37,231,272–37,232,043 | 265.1 kb | Distal (>10kb) Multiome | 891 |
Genomic view of the STRN locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.