This gene encodes a member of the serine/threonine kinase family of enzymes. This family member is similar to a Drosophila protein that plays a key role in the Hedgehog signaling pathway. This human protein is a positive regulator of the GLI zinc-finger transcription factors. Knockout studies of the homologous mouse gene suggest that defects in this human gene may lead to congenital hydrocephalus, possibly due to a functional defect in motile cilia. Because Hedgehog signaling is frequently activated in certain kinds of gastrointestinal cancers, it has been suggested that this gene is a target for the treatment of these cancers. Alternative splicing of this gene results in multiple transcript variants. [provided by RefSeq, Aug 2011]
Transcription factors with Perturb-seq knockdown data for STK36. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = STK36 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of STK36, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr2:218,387,091–218,388,220 | 284.4 kb | Distal (>10kb) Multiome | 514 | |
| chr2:218,395,568–218,397,399 | 276.1 kb | Distal (>10kb) Multiome | 1048 | |
| chr2:218,397,484–218,401,433 | 274.3 kb | Distal (>10kb) Multiome | 1114 | |
| chr2:218,405,424–218,407,478 | 265.8 kb | Distal (>10kb) Multiome | 1093 | |
| chr2:218,567,787–218,569,400 | 103.8 kb | Distal (>10kb) Multiome | 1083 | |
| chr2:218,658,668–218,660,011 | 12.7 kb | Distal (>10kb) Multiome | 870 | |
| chr2:218,671,689–218,672,558 | 225 bp | At TSS Multiome | 794 | |
| chr2:218,710,272–218,711,420 | 38.6 kb | Distal (>10kb) Multiome | 957 | |
| chr2:218,781,682–218,782,718 | 109.9 kb | Distal (>10kb) Multiome | 674 | |
| chr2:218,798,810–218,799,640 | 127.0 kb | Distal (>10kb) Multiome | 163 | |
| chr2:218,799,866–218,800,388 | 128.1 kb | Distal (>10kb) Multiome | 82 | |
| chr2:218,860,491–218,861,382 | 188.8 kb | Distal (>10kb) Multiome | 241 | |
| chr2:218,883,560–218,884,239 | 211.6 kb | Distal (>10kb) Multiome | 190 | |
| chr2:218,892,714–218,893,400 | 220.7 kb | Distal (>10kb) Multiome | 591 | |
| chr2:218,898,077–218,898,730 | 226.1 kb | Distal (>10kb) Multiome | 624 | |
| chr2:218,908,757–218,909,543 | 236.9 kb | Distal (>10kb) Multiome | 885 | |
| chr2:218,959,145–218,960,352 | 287.3 kb | Distal (>10kb) Multiome | 416 | |
| chr2:218,962,902–218,964,278 | 291.0 kb | Distal (>10kb) Multiome | 768 |
Genomic view of the STK36 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.