The protein encoded by this gene is a kinase that is predominantly found in the nucleus. However, it can interact with PDLIM1/CLP-36 in the cytoplasm and localize to actin stress fibers. The encoded protein may be a regulator of actin stress fibers in nonmuscle cells. [provided by RefSeq, Jul 2008]
Transcription factors with Perturb-seq knockdown data for STK35. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = STK35 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of STK35, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr20:1,803,072–1,803,979 | 299.3 kb | Distal (>10kb) Multiome | 242 | |
| chr20:1,891,492–1,892,371 | 211.0 kb | Distal (>10kb) Multiome | 91 | |
| chr20:1,894,295–1,895,549 | 208.2 kb | Distal (>10kb) Multiome | 355 | |
| chr20:1,947,071–1,947,639 | 155.6 kb | Distal (>10kb) Multiome | 254 | |
| chr20:2,050,312–2,050,930 | 52.3 kb | Distal (>10kb) Multiome | 15 | |
| chr20:2,101,606–2,103,515 | 485 bp | At TSS Multiome | 1091 | |
| chr20:2,207,018–2,207,984 | 104.6 kb | Distal (>10kb) Multiome | 658 | |
| chr20:2,351,893–2,352,388 | 249.2 kb | Distal (>10kb) Multiome | 361 |
Genomic view of the STK35 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.