This gene encodes a secreted, homodimeric glycoprotein that is expressed in a wide variety of tissues and may have autocrine or paracrine functions. The gene contains a 5' UTR rich in CAG trinucleotide repeats. The encoded protein contains 11 conserved cysteine residues and is phosphorylated by protein kinase C exclusively on its serine residues. The protein may play a role in the regulation of renal and intestinal calcium and phosphate transport, cell metabolism, or cellular calcium/phosphate homeostasis. Overexpression of human stanniocalcin 1 in mice produces high serum phosphate levels, dwarfism, and increased metabolic rate. This gene has altered expression in hepatocellular, ovarian, and breast cancers. [provided by RefSeq, Jul 2008]
Transcription factors with Perturb-seq knockdown data for STC1. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = STC1 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of STC1, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr8:23,682,166–23,683,403 | 171.9 kb | Distal (>10kb) Multiome | 655 | |
| chr8:23,706,237–23,707,411 | 148.0 kb | Distal (>10kb) Multiome | 215 | |
| chr8:23,709,392–23,710,292 | 144.9 kb | Distal (>10kb) Multiome | 98 | |
| chr8:23,714,334–23,715,166 | 140.1 kb | Distal (>10kb) Multiome | 334 | |
| chr8:23,785,542–23,786,124 | 69.0 kb | Distal (>10kb) Multiome | 146 | |
| chr8:23,853,202–23,854,956 | 17 bp | At TSS Multiome | 304 | |
| chr8:23,859,391–23,859,557 | 4.6 kb | Proximal (<10kb) | 64 | |
| chr8:23,861,767–23,862,300 | 7.0 kb | Proximal (<10kb) | 103 | |
| chr8:23,929,998–23,931,300 | 76.1 kb | Distal (>10kb) Multiome HiCAR | 174 | |
| chr8:23,979,118–23,979,822 | 124.6 kb | Distal (>10kb) Multiome HiCAR | 266 | |
| chr8:24,045,931–24,046,706 | 191.5 kb | Distal (>10kb) Multiome | 78 | |
| chr8:24,414,847–24,415,546 | 560.4 kb | Distal (>10kb) Multiome HiCAR | 251 |
Genomic view of the STC1 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.