This gene encodes the substrate of breast tumor kinase, an Src-type non-receptor tyrosine kinase. The encoded protein possesses domains and several tyrosine phosphorylation sites characteristic of adaptor proteins that mediate the interactions linking proteins involved in signal transduction pathways. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2008]
Transcription factors with Perturb-seq knockdown data for STAP2. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = STAP2 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of STAP2, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr19:4,064,058–4,067,782 | 272.9 kb | Distal (>10kb) Multiome | 811 | |
| chr19:4,123,681–4,124,581 | 214.6 kb | Distal (>10kb) Multiome | 798 | |
| chr19:4,182,102–4,182,890 | 156.3 kb | Distal (>10kb) Multiome | 862 | |
| chr19:4,198,066–4,198,600 | 140.5 kb | Distal (>10kb) Multiome | 214 | |
| chr19:4,246,623–4,247,617 | 91.5 kb | Distal (>10kb) Multiome | 960 | |
| chr19:4,326,625–4,329,107 | 10.3 kb | Distal (>10kb) Multiome | 567 | |
| chr19:4,329,263–4,329,852 | 9.0 kb | Proximal (<10kb) | 101 | |
| chr19:4,342,323–4,344,016 | 4.1 kb | Proximal (<10kb) Multiome | 969 | |
| chr19:4,390,525–4,391,068 | 51.9 kb | Distal (>10kb) Multiome | 464 | |
| chr19:4,399,835–4,401,019 | 61.8 kb | Distal (>10kb) Multiome | 828 | |
| chr19:4,402,106–4,403,050 | 63.7 kb | Distal (>10kb) Multiome | 731 | |
| chr19:4,456,541–4,458,172 | 119.0 kb | Distal (>10kb) Multiome | 757 | |
| chr19:4,471,202–4,472,545 | 133.1 kb | Distal (>10kb) Multiome | 715 | |
| chr19:4,474,252–4,474,874 | 135.9 kb | Distal (>10kb) Multiome | 201 | |
| chr19:4,534,817–4,535,416 | 196.4 kb | Distal (>10kb) Multiome | 451 | |
| chr19:4,556,056–4,556,977 | 217.9 kb | Distal (>10kb) Multiome | 259 | |
| chr19:4,581,475–4,581,916 | 243.0 kb | Distal (>10kb) Multiome | 358 | |
| chr19:4,597,380–4,598,540 | 259.3 kb | Distal (>10kb) Multiome | 280 | |
| chr19:4,633,303–4,633,826 | 294.7 kb | Distal (>10kb) Multiome | 500 | |
| chr19:4,636,101–4,636,717 | 297.6 kb | Distal (>10kb) Multiome | 445 |
Genomic view of the STAP2 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.