Cytokine-mediated signal transduction in the JAK-STAT cascade requires the involvement of adaptor molecules. One such signal-transducing adaptor molecule contains an SH3 domain that is required for induction of MYC and cell growth. The protein encoded by this gene binds to the SH3 domain of the signal-transducing adaptor molecule, and plays a critical role in cytokine-mediated signaling for MYC induction and cell cycle progression. Multiple alternatively spliced transcript variants encoding the same protein isoform have been found for this gene. [provided by RefSeq, Jul 2008]
Transcription factors with Perturb-seq knockdown data for STAMBP. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = STAMBP upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of STAMBP, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr2:73,707,107–73,707,579 | 121.7 kb | Distal (>10kb) Multiome | 38 | |
| chr2:73,736,841–73,737,678 | 91.5 kb | Distal (>10kb) Multiome | 952 | |
| chr2:73,779,673–73,780,474 | 48.8 kb | Distal (>10kb) Multiome | 767 | |
| chr2:73,828,734–73,829,492 | 14 bp | At TSS Multiome | 774 | |
| chr2:73,921,096–73,921,666 | 92.4 kb | Distal (>10kb) Multiome | 284 | |
| chr2:73,926,648–73,927,193 | 97.9 kb | Distal (>10kb) Multiome | 961 | |
| chr2:73,981,145–73,981,910 | 152.6 kb | Distal (>10kb) Multiome | 483 | |
| chr2:73,983,451–73,985,871 | 156.4 kb | Distal (>10kb) Multiome | 821 | |
| chr2:74,002,059–74,003,348 | 173.7 kb | Distal (>10kb) Multiome | 514 | |
| chr2:74,008,705–74,009,321 | 180.0 kb | Distal (>10kb) Multiome | 142 | |
| chr2:74,026,198–74,026,578 | 197.5 kb | Distal (>10kb) Multiome | 88 | |
| chr2:74,119,987–74,120,643 | 291.4 kb | Distal (>10kb) Multiome | 969 | |
| chr2:74,147,573–74,148,843 | 319.1 kb | Distal (>10kb) Multiome HiCAR | 884 |
Genomic view of the STAMBP locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.