The protein encoded by this gene is expressed in the nucleus and is a subunit of the cohesin complex which regulates the cohesion of sister chromatids during cell division. A mutation in this gene is associated with premature ovarian failure. Alternate splicing results in multiple transcript variants encoding distinct isoforms. This gene has multiple pseudogenes. [provided by RefSeq, Apr 2014]
Transcription factors with Perturb-seq knockdown data for STAG3. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = STAG3 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of STAG3, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr7:99,929,116–99,929,724 | 248.1 kb | Distal (>10kb) Multiome | 300 | |
| chr7:100,015,387–100,016,069 | 162.0 kb | Distal (>10kb) Multiome | 744 | |
| chr7:100,049,441–100,050,060 | 127.8 kb | Distal (>10kb) Multiome | 800 | |
| chr7:100,081,134–100,083,000 | 95.7 kb | Distal (>10kb) Multiome | 1160 | |
| chr7:100,088,454–100,089,460 | 88.6 kb | Distal (>10kb) Multiome | 955 | |
| chr7:100,100,270–100,102,380 | 76.9 kb | Distal (>10kb) Multiome | 1102 | |
| chr7:100,119,029–100,120,415 | 58.0 kb | Distal (>10kb) Multiome | 954 | |
| chr7:100,126,675–100,128,006 | 50.3 kb | Distal (>10kb) Multiome | 919 | |
| chr7:100,148,262–100,149,663 | 28.7 kb | Distal (>10kb) Multiome | 846 | |
| chr7:100,158,247–100,159,079 | 18.8 kb | Distal (>10kb) Multiome | 795 | |
| chr7:100,167,090–100,167,783 | 10.1 kb | Distal (>10kb) Multiome | 123 | |
| chr7:100,167,894–100,168,793 | 8.9 kb | Proximal (<10kb) Multiome | 439 | |
| chr7:100,171,153–100,171,887 | 6.1 kb | Proximal (<10kb) Multiome | 233 | |
| chr7:100,176,986–100,178,152 | 14 bp | At TSS Multiome | 626 | |
| chr7:100,266,531–100,267,045 | 89.2 kb | Distal (>10kb) Multiome | 24 | |
| chr7:100,270,225–100,270,813 | 93.1 kb | Distal (>10kb) Multiome | 103 | |
| chr7:100,271,732–100,272,774 | 94.8 kb | Distal (>10kb) Multiome | 530 | |
| chr7:100,335,652–100,336,470 | 158.5 kb | Distal (>10kb) Multiome | 706 | |
| chr7:100,381,682–100,382,670 | 204.5 kb | Distal (>10kb) Multiome | 49 | |
| chr7:100,428,059–100,431,175 | 251.4 kb | Distal (>10kb) Multiome | 1296 | |
| chr7:100,435,379–100,436,927 | 259.0 kb | Distal (>10kb) Multiome | 931 | |
| chr7:100,450,379–100,450,973 | 273.1 kb | Distal (>10kb) Multiome | 785 |
Genomic view of the STAG3 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.